GATE QUESTION PAPER (PHARMACY: PY) – 1988

 

GATE QUESTION PAPER (PHARMACY: PY) – 1988

Section I

Multiple choice Questions

Answers are marked as bold

1. To understand the drug receptor interaction is necessary to quantify the relation between …

a) Drug and its toxicity

b) Drug and its absorption

c) Drug and its biological effect

d) Drug and intermediate product

 

2. Penicillinase resistance penicillin is …

a) Amoxycillin

b) Ampicillin

c) Penicillin V

d) Methicillin

 

3. Morphine is present in …

a) Atropine belladonna

b) Papaver somniferum

c) Ricinus communis

d) Solanum nigrum

 

4. Ion exchange chromatography is the method of choice for separation of …

a) Metals

b) Sugar

c) Fatty acids

d) Sterols

 

5. Rideal Walker test is performed by using the strain …

a) Escherichia coli

b) Straphylococcus neruri

c) Straphylococcus pyrogenes

d) Salmonella typhii

 

6. Pheniramine maleate is an antihistaminic agent belonging to the class …

a) Ethylenediamine derivative

b) Cyclic basic class analogs

c) Aminoallyl ether analoges

d) None of the above

 

7.  Tetracycline undergo epimerization C-4 between pH 4 and 8 to give …

a) Isotetracyclines

b) Epitetracyclines

c) Nortetracyclines

d) None of the above

 

8. Tyndalisation means …

a) Successive autoclaving with a bactericide

b) Successive heating with a bactericide

c) Successive heating at low temperature

d) Successive autoclaving at low temperature and incubator.

 

9. Morphine and heroin differ from each other in respect of …

a) Methyl group on nitrogen

b) Acetyl groups at C3 and C6

c) Absence of double bond between C4 and C6

d) Absence of D ring

 

10. Vincristine and vinblastine act by …

a) Binding with the protein tubulin and arrest at metaphase

b) Inhibiting the protein synthesis

c) Acting as antimetabolite

d) Inhibiting the enzyme system

 

11. A rhamno-glucoside on complete hydrolysis will give …

a) Aglycon + Fructose + Rhamnose

b) Aglycon + Ribose + Rhamnose

c) Aglycon + Rhannose + Glucose

d) Rhamnose + Fructose

 

12. The technique employed to study the insoluble film at oil water interface is …

a) Micellization

b) Defloculation

c) Electrostatic balance

d) Film balance

 

13. Gray baby syndrome is due to the indiscrimate use of ….

a) Streptomycin

b) Chloramphenicol

c) Penicillin

d) Tetracycline

 

14. N, N dimethyl – [1-methyl-1-oxo-3,3-diphenylhexyl] ammonium chloride is the chemical …

a) Methadone hydrochloride

b) Alpha proline hydrochloride

c) Meperidine hydrochloride

d) Darvon

 

15. Suphonamide tragedy was due to combination with …

a) Penicillin

b) Streptomycin

c) Diethylene hydrochloride

d) Bicarbonate

 

16. In the preparation of tablets, powdered medicaments are mixed  …

a) To reduce the total volume

b) To increase adsorption

c) To increase adhesiveness

d) To reduce inter particle

 

17. One nanometer is equal to …

a) 10¹⁰ cm

b) 10^-4 cm

c) 10^-7 cm

d) 10^-8 cm

 

18. Cholinergic receptor present on intestinal muscle is …

a) H2 receptor

b) Muscarinic receptor

c) Nicotinic receptor

d) Beta receptor

 

19. Indicate the correct order of increasing eluent power of benzene, ether, chloroform and ethyl acetate …

a) Chloroform < Benzene < Ethyl acetate < Ether

b) Benzene < Ether < Chloroform < Ethyl acetate

c) Ether < Chloroform < Ethyl acetate < Benzene

d) Ethyl acetate < Ether < Benzene < Chloroform

 

20. Limulus test is rapid in vitro test for parenterals to detect the presence of …

a) Particulate matter

b) Fungus

c) Pyrogens

d) Bacteria

 

21. An essential requirements of the mobile phase in HPLC is that …

a) It must have constant flow rate with pulses

b) It must be freshly distilled

c) It must be run at 20^oC only

d) It must flow with pulses

 

22. Indian (Tinnevelly) and Africa seena leaves differ from each other with respect to …

a) Vein islet number

b) Stomatal index

c) Colour

d) All of the above

 

23. 3-Etherification of morphine molecules causes …

a) Morphine antagonism

b) No change in activity

c) Decrease of analgesic and addiction

d) Increase of analgesic and addition

 

 24. Addition of electrolyte to a Lysol may cause …

a) Tyndall effect

b) Salting out

c) Coagulation

d) Dilution

 

25. Salicin, a phenolic glycoside, on hydrolysis yields …

a) Salicylic alcohol + Glucose

b) Phenol + Glucose

c) Salicyl alcohol + Glucose

d) Salicyl aldehyde + Glucose

 

26. Lignocaine hydrochloride is officially assayed by …

a) Potentiometric titration

b) Acid base titration

c) Complexometric titration

d) Non aqueous titration

 

27. In supra ventricle arrthymia digoxin when supplemented with … is dangerous.

a) Quinidine

b) Procaine

c) Calcium

d) Xylocaine

 

28. Injection of insulin IP should be kept at pH between…

a) 5 and 5.5

b) 3 and 3.5

c) 7 and 7.5

d) 9 and 9.5

 

29. Some adrenocorticoids are referred to as D-corticoids because of …

a) High amount of unsaturation in the molecules

b) Additional double bond in ring A between carbon 1 and 2

c) Presence of one double bond in each ring

d) Absence of double bond in ring A

 

30. In radioactive pharmaceuticals half life of compounds means …

a) The time taken for one half of the compound to find with serum albumin

b) The time taken for onset of its action

c) The time taken for the activity to decay to one half of its initial value

d) The time taken for its complete metabolism

 

31. Wagners test is used to detect the presence of …

a) Steroids

b) Alkaloids

c) Glycosides

d) Terpenes

 

32. Metronidazole inhibits anaerobic bacteria and protozoa by …

a) Affecting the structure of DNA molecule of the organism

b) Destroying the ribosome

c) Inhibiting the cytochrome system

d) Inhibiting the protein synthesis

 

33. Most common oestrogen progesterone preparation used as oral contraceptive agent contains …

a) Methanol + Progesterone

b) Estrone + Progesterone

c) Diethyl stillbestrol + Norgestrol

d) Ethinyloestradiol + Norethindrone

 

34. Before washing the ampoules the mouth of each ampoule is rotated in Bunson flame to melt down the rough edge. This process is called as …

a) Flamming

b) Charging

c) Annacaling

d) Grounding

 

35. In benzothiadiazides reduction of the double bond between the position 3 and 4 gives rise to …

a) Decreased diuretic activity

b) Increase the diuretic activity

c) No diuretic activity

d) No change in diuretic activity

 

36. Peripherial neurotransmitter is …

a) Histamine

b) Noradrenalin

c) Hydroxytryptamine

d) Prostaglandin

 

37. Beer’s law state that …

a) Absorbance of a solution is indirectly proportional to the absorbing solute

b) Absorbance of a solution is indirectly proportional to the length of cell

c) Absorbance of a solution is directly proportional to the absorbing solute

d) Transmittance of a solution is directly proportional to the absorbance solvent


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