GATE QUESTION PAPER (PHARMACY: PY) – 1989

 Multiple choice Questions

 

1. Repeated administration of Tyramine results in its decreasing effectiveness:

a) Gets detoxicated easily

b) Displaces nor-adrenalin from nerve ending binding site

c) Displaces adrenaline from nerve ending binding site

d) None of the above

 

2. Atropine on hydrolysis with Barium hydroxide gives:

a) Tropanol and Tropic acid

b) Scopine and Tropic acid

c) Ecgonine and Benzoic acid

d) Benzyl Ecgonine and Methanol

 

3. The concentration of sucrose in Simple Syrup BP is …

a) 85% w/w

b) 60.70% w/w

c) 66.70% w/w

d) 40.74% w/w

 

4. Stratified cork and forked are the characteristic diagnostic features of:

a) Apocynaceae

b) Scrophularaceae

c) Gentianaceae

d) Polygonaceae

 

5. Most accepted mechanism for developing bacterial resistance to sulphonamides is …

a) An increasing capacity to inactivate or destroy the drug

b) An alternative metabolic pathway for synthesis of an essential metabolite

c) An increasing product of drug antagonist

d) An alternation in enzyme that utilize PABA

 

6. C 17 alpha-beta unsaturated lactone ring is a common feature in …

a) Digitalis and squill glycosides

b) Digitalis and stropanthus glycosides

c) Digitalis and Senna glycosides

d) Digitalis and amygdalin

 

7. For drying blood plasma the following technique is used:

a) Spray drying

b) Freeze drying

c) Vacuum drying

d) Fluid bed drying

  

8. C3 O-glycoside digitoxin is used for …

a) Cardiac action

b) Hypotensive action

c) Precipitating steroids from solution

d) Precipitating anthraquinone glycosides

 

9. Chemical name of amoxicillin is …

a) 6- [D-(-) alpha- amino p-hydroxyacetamido] penicillanic acid

b) 4- [D-(-) alpha- amino p-hydroxyacetamido] penicillanic acid

c) Beta- Hydroxy analogue of Benzyl penicillin

d) Alpha- Carboxy benzyl penicillin

 

10. The HLB value of sodium lauryl sulphate is …

a) 6.5

b) 13.8

c) 25.0

d) 40.0

 

11. Claviceps purpurea yields after infecting ovaries of Graminaceous plants:

a) Digitoxin

b) Lysergic acid derivatives

c) Reserpine

d) Polypeptides

 

12. In the official bioassay erythromycin strain used is …

a) Bacillus subtilis

b) Micrococcus luteus

c) Salmonella typii

d) Escherichia coli

 

13. The disintegration time for sugar coated tablet is …

a) 30 minutes

b) 45 minutes

c) 60 minutes

d) 75 minutes

 

14. Idioblasts of crystal layer of calcium oxalate is a diagnostic feature of …

a) Hyoscyamus Niger leaves

b) Deadly nightshade leaves

c) Cinchona bark

d) Senna leaves

 

15. Antibiotics which interacts with calcium ion is …

a) Erythromycin

b) Streptomycin

c) Tetracycline

d) Ampicillin

 

16. Flow rate of granules from the hopper can be improved by adding …

a) Disintegrant

b) Glidant

c) Binder

d) Lubricant

 

17. Silicon carbide rod heated to a high temperature is used as a …

a) Detector in infra red spectroscope

b) Source of light in infra red spectroscope

c) Source of light fluorimetry

d) Detector in gas chromatography

 

18. Anomocytic type stomata are found in the leaves of …

a) Fox glove

b) Urginea maritime

c) Cassia acutifolia

d) Atropa belladonna

 

19. Liver microsomal enzymes are stimulated (enzyme induction) by:

a) Cimetidine

b) Phenobarbitone

c) Procaine

d) Adrenaline

 

20. Enteric coating is achieved by using …

a) Hydroxy propyl methyl cellulose

b) Carboxy methyl cellulose

c) Cellulose acetate phthalate

d) Povidone

 

21. Car price reaction is applied for the photometric evaluation of …

a) Vitamin A

b) Tocopherol

c) Nandrolone phenyl propionate

d) Benzodiazepine

 

22. Peroxide enzyme present in acacia is identified by …

a) Borntragers test

b) Molisch’s test

c) Oxidation and extraction in benzene

d) Oxidation and treatment with benzidine

 

23. Prostaglandins are a group of related

a) Alcohols

b) Aldehydes

c) Fatty acids

d) Alkaloids

 

24. Licence to sell drug specified in schedule C and C1 is given from number …

a) -19

b) -18

c) -21

d) -24

 

25. Liquid paraffin exhibits …

a) Plastic flow

b) Newtonian flow

c) Pseudoplastic flow

d) Dilatant flow

 

26. Estrogenic and progestrogenic combination mainly …

a) Inhibits the ovulation

b) Inhibits the implantation of the fertilized ovum

c) Inhibits the fertilization of ovum

d) Inhibits development of endometrium

 

 27. More of earthy matter in a rhizome is determined by …

a) Total ash value

b) The earthy material is separated and then weighed

c) The rhizome is washed in water and the in hydrochloric acid finally it is weighed

d) Acid insoluble ash value

 

28. Lidocaine is synthesized from …

a) 2: 6-dimethyl-5-amino methyl benzene

b) 2: 6-dimethyl-5-nitro methyl benzene

c) 2: 6-xylidine

d) 2-methyl- 6-ethyl-5-amino methyl benzene

 

29. Sterilization temperature for aqueous solution in autoclave is …

a) 72 degree C

b) 121 degree C

c) 147 degree C

d) 160 degree C

 

30. Following combination is suggested in the treatment of leprosy …

a) Dapsone + Ampicillin + Clofazimine

b) Dapsone + Clofazimine + Rifampin

c) Dapsone + Erythromycin + Rifampin

d) Dapsone + Tetracycline + Streptomycine

 

31. The gummy nature Astragalus gummifer is depend on …

a) More of methoxy group Bassorin

b) The carbohydrate content

c) More of hydroxyl groups of the sugar moiety

d) More of protein contain of the drug

 

32. The vitamin administered with isoniazide to minimize its adverse reaction is …

a) Vitamin A

b) Pyridoxine

c) Biotin

d) Pantothenic acid

 

33. For the synthesis of Nitrofurantoin which one of the following combination of chemicals are used …

a) 5-Nitro 2-furaldehyde and 2-amino hydantoin

b) 5-Nitro 2-furaldehyde and hydantoin

c) 5-amino 2-furaldehyde and 2-amino hydantoin

d) 5-Nitro 2-furaldehyde and barbituric acid

 

34. To get the optimum optical density of the solution form 1 cm thick layer the concentration should be about …

a) 10 rest to -4 mole/lit

b) 10 rest to -7 mole/lit

c) 0.1 gm/lit

d) 0.5 gm/lit

 

35. The sugar moiety of Digitalis purpurea is …

a) 2: 6-deoxy allose

b) 2: 6-deoxy glucose

c) 2: 6-deoxy rhamnose

d) 2: 6-deoxy galactose

 

36. Additional of sodium chloride to sodium oleate emulsion will …

a) Stabilize emulsion

b) Destabilize emulsion

c) Decrease the globule size of the emulsion

d) None of the above

 

37. Anti hypertensive drug inhibits the rennin angiotensin system is …

a) Reserpine

b) Captopril

c) Methyl dopa

d) Propranolol

 

38. Acidity of Ascorbic acid is due to the presence of …

a) Free carboxylic acid

b) A number of hydroxyl group

c) Enolic groups

d) None of the above

 

39. Progesterone injection BP is a sterile solution in …

a) Water

b) Ethyl oleate

c) Propylene glycol

d) Glycerol

 

40. Thiamine on treatment with sodium sulfite solution and sulfur dioxide yields …

a) Pyrimidine and a thiazole derivative

b) Pyridine and thiazole derivative

c) 2: 3: 4- Thihydropyridine and Thiophene derivative

d) Pyrimidine and Thiophene derivatives

More Practice Tests Join Telegram:
Videos: https://t.me/PharmaExcel
MCQs: https://t.me/drkailasmali4u