GATE QUESTION PAPER (PHARMACY: PY) – 1990

 Multiple choice Questions

1.1 Reserpine on hydrolysis gives :

(a) Reserpic acid + Methyl alcohol + Trimethoxy cinnamic acid

(b) Reserpic acid + Acetic acid + Trimethoxy benzaldehyde

(c) Reserpic acid + Methyl alcohol + Trimethoxy benzoic acid

(d) Reserpic acid + Methyl alcohol + Trimethoxy cinnamaldehyde

 

1.2 Papaverine is

(a) 6, 7 - dimethoxy -1- (3’, 4’ – dimethoxy benzyl) isoquinoline

(b) 6, 7 - dimethoxy -1- (3’, 4’ – dimethyl benzyl) isoquinoline

(c) 6, 7 - dimethoxy -1- (3’, 4’ – dimethoxy benzyl) quinoline

(d) 6, 7 - dimethoxy -1- (3’, 4’ – dimethyl benzyl) quinoline

 

1.3 Titanium dioxide is commonly present in

(a) Vanishing cream

(b) Sunscreen cream

(c) Aqueous calamine cream

(d) Ophthalmic cream

 

1.4 Powder ergot when treated with sodium hydroxide solution develops :

(a) A strong odour of ammonia

(b) A strong odour of trimethyl amine

(c) A strong odour of indol

(d) A strong odour of urea

 

1.5 Salbutamol sulphate IP is assayed by

(a) Direct titration with standard sodium hydroxide solution

(b) Direct titration with standard sodium hydrochloric acid

(c) A known amount of standard acid is added and excess is titrated with standard alkali

(d) Dissolve in glacial acetic acid and titrated with standard perchloric acid using

oracet blue.

 

1.6 Heparin prevent blood coagulation by

(a) Inhibiting thrombin catalysed conversion of fibrinogen to fibrin

(b) Precipitate blood calcium thereby prevent coagulation reactions

(c) Inhibiting enzyme reactions

(d) Converting ionized calcium into chelation

 

1.7 For the registration of pharmacist in the various states, the Pharmacy Act provide for the constitution of:

(a) Registration of tribunals

(b) Registrar of Co-operative societies

(c) Registrar of state pharmacy council

(d) Registrar of central pharmacy council

 

1.8 Powder digitalis is dried at temperature:

(a) Not exceeded 60 ºC

(b) 65 ºC

(c) 75 ºC

(d) 100 ºC

 

1.9 Prazepam differ in structure from diazepam by

(a) N- methyl group

(b) N –cyclopropyl group

(c) N-cyclopropyl methyl group

(d) N-propyl group

 

1.10 The mechanism of action of rifampicin involve

(a) Inhibition of bacterial DNA directed RNA polymerase

(b) Inhibition of mycolic acid synthesis

(c) Inhibition of protein synthesis

(d) Inhibition of transpeptidase

 

1.11 The UV- visible region in the electromagnetic spectrum of radiation is

(a) 200 - 400 nm

(b) 300 – 660 nm

(c) 400 -800 nm

(d) 200 -800 nm

 

1.12 The mantoux test uses :

(a) Old tuberculin

(b) Diptheria toxins

(c) Serum antigens

(d) Polysaccharide antigens

 

1.13 Rotosort is a machine used to sort out :

(a) Coated tablets

(b) Filled capsule

(c) Sealed ampoules

(d) Sealed containers

 

1.14 The volume of distribution of drugs is:

(a) An expression of total body volume

(b) A measure of total fluid volume

(c) A relationship between the total amount of drug in the body and the concentration of the drug in the blood

(d) Proportional to bioavailability of the drug

 

 1.15. Resolution of a spectrophotometer is :

(a) It’s a wavelength range

(b) Its ability to distinguish adjacent absorption bands

(c) It’s a capacity for its continuous use

(d) Its power to gather light according to source

 

1.16 Heloperidol is a major transquillizer. It belongs to the class of

(a) Carbamates

(b) Propanediol

(c) Butarophenone

(d) Phenothiazine

 

1.17 Glandular hair growing having a unicellular or occasionally a short uniserate pedicel with a unicellular or bicellular terminal gland is characteristics of

(a) Senna leaves

(b) Belladonna leaves

(c) Datura stramonium leaves

(d) Digitalis Purpurea leaves

 

1.18 Skeletal muscle relation produced by the drug ______is effectively antagonized by neostigmine

(a) Diazepam

(b) Succinylcholine

(c) Tubocurarine

(d) Aminophylline

 

1.19 Vitamin D2 is :

(a) 22, 23-Dihydro -5, 6 cis –ergocalciferol

(b) 5, 6 cis- chlorcalciferol

(c) 7- dehydrocholesterol

(d) 21, 24 – dihydro 5, 6 cis ergocalciferol

 

1.20 R.W. C. is used to identify the strength of an :

(a) Antibiotics

(b) Antipyretics

(c) Antiseptic

(d) Antiinflammatory

 

1.21 The colligative property are related to the

(a) Total number of solute particles

(b) pH

(c) Number of ions

(d) Number of ingredients

  

1.22 The essential structural unit for the anthelmentics activity of mebendazole is

(a) Benzoyl group

(b) Benzimidazole

(c) Methyl carbamates

(d) Imidazole

 

1.23 The anticoagulant activity of heparin sodium injection IP is estimated using :

(a) Female rats

(b) male rats

(c) Rabbits

(d) Sheep

 

1.24 The biological half-life of a drug (first order kinetics) is represented by

(a) 1/K

(b) Log K

(c) 0.693/ K

(d) 2.303 / K

 

1.25 Infra red spectroscopy is a convenient method for understanding of

(a) Drug receptor interaction

(b) Functional group identification

(c) Physiochemical properties

(d) Conformational properties

 

1.26 Most commonly used amtimicrobial agent for intraperitoneal dialysis is

(a) Chlorocresol

(b) Benzalkonium chloride

(c) Isopropyl alcohol

(d) None of the above

 

1.27 In the steroid nucleus, they are

(a) Six chiral center with nucleus i.e. 5,8,9,10,13, and 14

(b) Seven chiral center with nucleus i.e. 3,8,9,10,11, 12 and 14

(c) Six chiral center with nucleus i.e. 3,8,9,10,11, and 12

(d) Six chiral center with nucleus i.e. 5,7,9,10,13, and 16

 

1.28 Thermolabile immiscible liquid can be separated by

(a) Decantation

(b) Dilution

(c) Capacity centrifugation

(d) Counter current distribution

 

1.29 Sulphomethoxazole is a antibacterial drug. It is a

(a) Short acting drug

(b) Short and intermediate acting drugs

(c) Long acting drugs

(d) Mixed acting drugs

 

1.30 Wave number is the number of waves

(a) Per second

(b) per centimeter

(c) per inch

(d) per cm3

 

1.31 The raw material for synthesis of propranolol is

(a) α – Napthylamine

(b) β naphthol

(c) α naphthol

(d) 1- nepthaldehyde

 

1.32 All the statement mentioned below about choral hydrate is true EXCEPT that it

(a) Produces hypnosis

(b) Produces analgesia

(c) Produce dependence

(d) Irritate gastric mucosa

 

1.33 In drug and cosmetics act and rules thereunder, list of substances that should be sold by retail only on prescription of registered practitioner is given in

(a) Schedule H

(b) Schedule V

(c) Schedule X

(d) Schedule Q

 

1.34 Which is ideal combination for testing the solubility of an enteric coated capsule in alkaline medium?

(a) Sodium bicarbobnate + Potassium hydroxide + Pepsin

(b) Sodium bicarbobnate + Sodium tauroglycocholate + Papain

(c) Sodium bicarbobnate + Pancreatin + Sodium tauroglycocholate

(d) Sodium bicarbobnate + Billirubin

 

1.35 Oxazepam is used in relief of psychoneurosis. It has lower incidents of side effects and reduced toxicity due to

(a) N-demethylation

(b) Ring oxidation

(c) Aromatic hydroxylation

(d) Conjugation of 3- hydroxyl group

 

1.36 The rate of diffusion of drug across biological membrane is

(a) Directly proportional to the concentration gradients

(b) Dependent on route of administration

(c) Indirectly proportional to membrane thickness

(d) None of the above

1.37 In sugar coating of tablets subcoating is done

(a) To prevent moisture deposition

(b) To round the edge and build tablet size

(c) To smoothen the surface

(d) To prevent the tablet from breaking due to vibration

 

1.38 One of the detectors used in gas chromatography

(a) Bolometer

(b) Thermal conductivity detector

(c) Golay detectors

(d) Giger Counter

 

1.39 Alkloids in chinchona bark are detected by

(a) Iodine test

(b) Thalleioquine test

(c) Liebermann –burchard test

(d) Nessler’s test

 

1.40 2- amino -5-chorbenzophenone is the convenient starting material for the synthesis of

(a) Nitrazepam

(b) Diazepam

(c) Choramphenicol

(d) Trimethoprim

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