GATE QUESTION PAPER (PHARMACY: PY) – 1991

Multiple Choice Questions 

1.1 Cortisone is

(a) 4 – Pregnane-12 a, 21 diol- 3, 20- dione

(b) 4 – Pregnane-17 a, 21 diol- 3, 11, 20- triione

(c) 4 – Pregnane-16 a, 21 diol- 3, 11, 20- triione

(d) 4 – Pregnane-17 a, 21 diol- 3, 11, - dione

 

1.2 Pregnenolone, an intermediate in synthesis of steroids, on oppeneur oxidation gives

(a) Progesterone

(b) 9α- flurocortisone

(c) Triamcinolone

(d) α methyl Prednisolone

 

1.3 In congestive cardiac failure, digitalis glycosides are used because it increases

(a) The heart rate

(b) The force of myocardial contraction

(c) The venous pressure

(d) The cardiac filling pressure

 

1.4 Shrinkage of gel by extrusion of lipids is called as

(a) Syneresis

(b) Dilatancy

(c) Plasticiy

(d) Ebulition

 

1.5 The sweetening agent commonly used in chewable tablet formula is

(a) Sucrose

(b) Cyclamate Sodium

(c) Saccharin Sodium

(d) Mannitol

 

1.6 Carbamazepine is tricyclic antidepressant, It is classified as

(a) Benzodiazepine

(b) Arylalkonolamine

(c) Iminostilbene

(d) Benzimidazole

 

1.7 Sulfa drugs can be conveniently estimated using the reagent

(a) 4,4 Dithiobis – (2-nitrobenzoic acid)

(b) Tris-(hydroxyl methyl) amino methane sodium nitrate

(c) N-(1-nepthyl) ethylene diamine

(d) N-ethylmalcimide

 

1.8 Testosterone can be commercially synthesis from

(a) Sarsapogenin

(b) Mexogenin

(c) Oubagenin

(d) Halotensin

 

1.9 Ehlrich’s reagent is

(a) Bismuth iodide solution

(b) p-dimethyl aniline solution in alcohol

(c) p-dimethyl amino benzaldehyde solution

(d) p-dimethyl aniline solution in alcohol

 

1.10 The neurotransmitter is released at the sympathetic nerve fiber is

(a) Epinephrine

(b) Norepinephrine

(c) Acetylcholine

(d) Physostigmine

 

1.11 The dose of the drug is 5 mg/kg body weight, How much the drug is required for the boy of 12 years who weigh 21 kg?

(a) 0.5 mg

(b) 1.0 mg

(c) 1.5 mg

(d) 2.0 mg

 

1.12 Rancidity of fat is due to ….

(a) Oxidation

(b) Saponification

(c) Hydrolysis

(d) Neutralization

 

1.13 Resolution of monochromator is the ability to distinguish …

(a) As a separate entities adjacent spectral features

(b) Separation of different colours

(c) Separation of UV light and Visible light

(d) Dispersing Characteristics

 

1.14 Important activity noticed in testosterone

(a) Androgenic, Myotropic and Anabolic

(b) Progestinal, Myotropic and Anabolic

(c) Estrogenic, Myotropic and Anabolic

(d) Androgenic, Optometric and Catabolic

  

1.15 Fruits which are derived from plants Umbiliferae are all of the type

(a) Cremocarp

(b) Pericarp

(c) Epicarp

(d) Mesocarp

 

1.16 Amygdalin on hydrolysis gives

(a) Mendelonitrile + Benzaldehyde

(b) Mendelonitrile + Benzaldehyde + Glucose

(c) Mendelonitrile + Glucose

(d) Mendelonitrile + Benzaldehyde + Rhamnose

 

1.17 Erythromycin is an antibiotic. It belong to the class of

(a) β-lactum

b) Aminoglycoside

(c) Macrolide

(d) Peptide

 

1.18 Vinblastin and Vincristine act by

(a) Interfering with synthesis of transfer RNA

(b) Inhibition of fragmentation of DNA

(c) Binding to protein

(d) Incorporating into folic acid metabolism

 

1.19 Water attack test is used to identity the alkalinity in

(a) Type I glass

(b) Type II glass

(c) Type III glass

(d) All the three types

 

1.20 Select the drug that will aggravates bronchial asthma

(a) Amphetamine

(b) Morphine

(c) Propranolol

(d) Tubocurarine

 

1.21 The presence of unpaired electron in metal ion complex meant for special analysis is called

(a) Paramagnetic

(b) Dimagnetic

(c) Bimagnetic

(d) Unimagnetic

 

1.22 The biological half- life of drug

(a) It is a constant physical property of the drug

(b) It is a constant chemical property of the drug

(c) It may be increased in patients with impaired renal failure

(d) It may be decreased in patients by giving the drug by rapid IV injection

 

1.23 The ilkovic equation in the polarographiac measurements is given by B

 

1.24 The vitamin which has deodorant property is

(a) Vitamin A

(b) Vitamin C

(c) Vitamin D

(d) Vitamin E

 

1.25 A type of flow in which viscosity increases when the substance agitated is

(a) Plastic

(b) Pseudoplastic

(c) Dilatant

(d) Thixotropy

 

1.26 Subcoating is given to the tablets

(a) To increase the bulk

(b) To avoid deterioration due to microbial attack

(c) To prevent the solubility of in acidic media

(d) To avoid stickiness

 

1.27 Water resistance of glass container are tested by measuring

(a) Amount of alkali released into water

(b) Amount of acid released into water

(c) Estimation of silicate level

(d) Turbidity

 

1.28 The pH of pharmaceutical buffer system can be calculated by

(a) pH partition theory

(b) Noyes whitney law

(c) Henderson-Hasselbaltch equation

(d) Michalis Menten Equations

1.30 The stationary phase in TLC is

(a) Adsorbent

(b) Liquid held between glass plate and adsorbent

(c) Glass plates

(d) None of the above

 

1.31Digoxin:

(a) has its action terminated by metabolism in the liver

(b) has a plasma t1/2 of 6 hours

(c) should be given half of its normal dose to hypothyroid patients

(d) provide benefit in atrial fibrillation by increasing the force of contraction

 

1.32 The ingredients mentioned below are commonly used as the coating agents for film coating EXCEPT

(a) Cellulose acetate phthalate

(b) Carnauba wax

(c) Hydroxy ethyl cellulose

(d) Sodium carboxy methyl cellulose

 

1.33 Morphine is the drug of choice for

(a) Urinary tract infection

(b) Colic pain

(c) Bronchial asthma

(d) Cardiac asthma

 

1.34 Drug used in treatment of bronchial asthma usually

(a) Block both α and β adrenergic receptors

(b) Stimulate α receptors but block β receptor.

(c) Stimulate β receptors but block α receptor.

(d) Stimulate α and / or β receptors

1.35 The formula for the preparation of ascorbic acid injection I.P. may include

(a) Glacial acetic acid

(b) Dilute hydrochloric acid

(c) Propylene glycol

(d) Sodium carbonate / sodium bicarbonate or sodium hydroxide in water

1.37 Lactose is the most widely used diluent in the tablet formulation. However it is not used in the formulation of one of the following

(a) Pyrazinamide

(b) Ibuprofen

(c) Sulfacetamide

(d) Isoniazide

 

1.38 The area under the serum concentration time curve of the drug represents:

(a) The biological half life of the drug

(b) The amount of drug in the original dosage from

(c) The amount of drug absorbed

(d) The amount of drug excreted in the urine

 

1.39 Vinca alkaloids are isolated from

(a) Catharanthus roseus and contain indole and indoline moieties

(b) Rosco chromogens and contain indole and indoline moieties

(c) Catharanthus roseus and contain quinoline and quinaldine moieties

(d) Catharanthus indicus and contain indole and quinoline moieties

 

1.40 Aprotic solvent have

(a) Acidic properties

(b) Basic properties

(c) Both acidic and basic properties

(d) No acidic and basic properties 

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