GATE QUESTION PAPER (PHARMACY: PY) – 1992

 1. Multiple Choice Questions

1.1 Simethicone is a component of several antacid formulations. Chemically it is

(a) wax

(b) fat

(c) Aldehyde

(d) silicon

 

1.2 The pharmacy Council of India is constituted by the

(a) Central Government

(b) State Government

(c) Parliament

(d) Legislative Assembly

 

1.3 All of the following physicochemical constants are useful in predicting the solubility of a drug except

(a) Dielectric constants

(b) pH of a solution

(c) pKa of the drug

(d) Valency

 

1.4 Sigma blade mixers are commonly used in …

(a) Wet granulation

(b) Dry granulation

(c) Powder mixing

(d) Crude fibre mixing

 

1.5 The 5β pregnane is said to have a

(a) trans-anti-trans-anti-trans back bone

(b) cis-anti-trans-anti-trans back bone

(c) cis-syn-trans-syn-trans back bone

(d) trans-anti-cis-anti-cis back bone

 

1.6 Many drugs are chiral. In a synthesis of chiral drug molecules in symmetric environment

(a) Always one enantiomer is obtained

(b) Always both enantiomers is obtained in equal amounts

(c) Always both enantiomers is obtained in unequal amounts

(d) None of the above

  

1.7 Poorly manufactured tablets may have small pinholes on the surface. This phenomenon is known as

(a) Picking

(b) Mottling

(c) Leaching

(d) Cracking

 

1.8 Ascorbic acid exists in nature

(a) Only in the reduced form which has only biological activity

(b) Only in the oxidized form which has only biological activity

(c) In both reduced and the oxidized forms in the state of reversible equilibrium which has biological activity

(d) None of the above

 

1.9 In the stable conformation of 5 α -pregnane

(a) Rings A, B, C are in boat conformation

(b) Rings A and B are in boat while C in chair conformation

(c) Ring A is in boat while B and C in chair conformation

(d) all the three rings are in chair conformation

 

1.10 Among the following preparations, which one will be the most irritating to the eye?

(a) Purified water

(b) 0.7% NaCl solution

(c) 0.9% NaCl solution

(d) 1% NaCl solution

 

1.11 In case of hypothyroidism, the preferred thyroid preparation is

(a) Levothyroxine

(b) Dextrothyroxine

(c) Leothyroxine

(d) None of the above

 

1.12 D-Fructose on simple reduction gives

(a) L-Fructose

(b) only Sorbitol

(c) Mannitol

(d) Mixture of Mannitol and Sorbitol

 

1.13 Lugol’s solution contains 5% of iodine. How much of Lugol’s solution is administered to a patient thrice daily to provide 60 mg of iodine daily?

(a) 0.2 ml

(b) 0.3 ml

(c) 0.4 ml

(d) 0.5 ml

 

1.14 The anticoagulant Heparin is obtained from …

(a) Sheep‘s lung

(b) Dog‘s kidney

(c) Rabit‘s heart

(d) Rat‘s uterus

 

1.15 Which one of the following types of adverse drug reactions are not believed to be dose related phenomenon?

(a) Side effects and toxic reactions

(b) Toxic reactions and hypersensitivity

(c) Side effects and hypersensitivity

(d) Hypersensitivity and idiosyncrasy

1.17 Cryoscopic method is familiar in the calculations of isotonic solutions. This method is based on …

(a) freezing point depression of the drug

(b) molecular concentration of the drug

(c) pH of the drug

(d) none of the above

 

1.18 One thousand nanogram equal to one …

(a) centrigram

(b) gram

(c) kilogram

(d) microgram

 

1.19. Biological role of thiamine is because of facile formation of

(a) Thiamine hydrochloride

(b) Thiamine pyrophosphate —yild―

(c) Thiamine sulphate

(d) None of the above

1.20. Infected blood products may produce serum hepatitis due to the presence of

(a) Hepatitis A virus

(b) Hepatitis B virus

(c) Hepatitis C virus

(d) None of the above

 

1.21. pH of a buffer system can be calculated by using

(a) pH partition theory

(b) Noyes-Whilney law

(c) Henderson-Hasselbalch equation

(d) None of the above

 

1.22. Osmolality measures the total number of particles dissolved in a … of water and depends on the electrolytic nature of the solute.

(a) kilogram

(b) kilolitre

(c) litre

(d) specified quantity

 

1.23. Ergot is the sclerotium of …

(a) fungus Claviceps purpurea

(b) fungus Claviceps notatum

(c) Strychnos nuxpotatorum

(d) fungus Pencillium chrysogenum

 

1.24. A highly sensitive semiquantitative method of detecting microbial antigen in biological fluid is done by

(a) Radio immune electrophoresis

(b) Counter immune electrophoresis

(c) H.P.L.C

(d) Freeze dried centrifugal method

 

1.25 The glass electrode used in pH measurements is

(a) metal-metaloxide electrode

(b) a membrane electrode

(c) Ion selective electrode

(d) none of the above

 

1.26 In phenonthiazine tranquillizing agents, replacement of C-2 hydrogen by chlorine

(a) Decreases activity

(b) Increases activity

(c) Activity unaffected

(d) Leads to decreased penetration into the CNS

 

 

1.27 The loading dose of a drug is based upon the

(a) time taken for complete elimination

(b) percentage of drug excreted unchanged in urine

(c) percentage of drug bound to plasma protein

(d) apparent volume of distribution and the desired drug concentration in plasma

 

1.28 Conformation of drugs is commonly determined by

(a) NMR

(b) NMI

(c) Mass spectrometry

(d) pH determination

 

1.29 Aminophylline solutions on exposure to air may develop

(a) Crystals of theophylline

(b) Precipitate of aminophylline

(c) Precipitate of ethylene diamine

(d) Straw colour

 

1.30 The hypotensive effect of clonidine is due to its action on

(a) β -adrenergic receptor

(b) α -adrenergic receptor

(c) H2 -receptor

(d) H1 -receptor

1.32 Sodium nitropruside is one of the most potent blood-pressure lowering drugs. Its use is limited because of

(a) its short duration of action

(b) very long duration of action

(c) ineffective of oral route

(d) none of the above

  

1.33 Cocaine is a monoacid tertiary base which on treatment with hot dilute acids gives

(a) ecogonine, methyl alcohol and scopic acid

(b) ecogonine, methyl alcohol and cinnamic acid

(c) ecogonine, methyl alcohol and benzoic acid

(d) ecogonine, ethyl alcohol and benzoic acid

 

1.34 Use of Isoniazid is restricted due to

(a) Ototoxicity

(b) Hepatotoxicity

(c) Neutrotoxicity

(d) Bone marrow depression

 

1.35 Diosgenin is

(a) an alkaloid obtained from dioscorea

(b) a carbohydrate obtained from dioscorea

(c) a glycoside obtained from dioscorea

(d) none of the above

1.37 Bubble point test is done to determine

(a) the surface tension of the liquid in capillary tubes

(b) the viscosity of the liquid in ampoules

(c) the pH of a 1% solution

(d) the volume of the solution stored in a specified container

 

1.38 The … Hemiacetal‖ form of aldosterone is between

(a) C-11, ß -hydroxyl and C-20 carbonyl

(b) C-11, ß -hydroxyl and C-21 hydroxy

(c) C-11, ß -hydroxy and C-18 carbonyl

(d) C-21, hydroxyl and C-20 carbonyl

 

1.39 Surfactants are characterized by the presence of

(a) water solubilizing and fat solubilizing groups in the same molecule

(b) only negative charges

(c) only positive charges

(d) none of the above

 

1.40 Acetous perchloric acid solution a common titrant in non-aqueous titrimetry is standardized by

(a) standard alcoholic KOH solution

(b) N/10 Potassium permanganate

(c) Potassium hydrogen phthalate solution in glacial acetic acid

(d) mercuric acetate in glacial acetic acid 

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