GATE QUESTION PAPER (PHARMACY: PY) – 1994

1.Multiple Choice Questions

1.1 Natural Camphor is:

(a) an optically inactive aldehyde obtained from Cinnamomum camphora

(b) a white dextrorotatory ketone obtained from the wood of Cinnamomum camphora

(c) a white optically inactive ketone obtained form the bark of Cinnamomum camphora

(d) a white volatile aldehyde obtained from the bark of Cinnamomum camphora

 

1.2 Ingredients used for capsulation in soft capsule should flow by gravity at a temperature

not exceeding

(a) 35°C

(b) 30°C

(c) 25°C

(d) 20°C

 

1.3 The region of the electromagnetic spectrum below 200 nm is known as

(a) vacuum ultra violet region

(b) far UV region

(c) low UV region

(d) microwave region

 

1.4 O/W micro emulsion containing hydrophilic surfactant produces

(a) translucent emulsion

(b) transparent emulsion

(c) milky white emulsion

(d) intense white emulsion

 

1.5 Which of the following steroids shows predominant mineralo corticoid action?

(a) Hydrocortisone

(b) Spironolactone

(c) Dexamethasone

(d) Fludrocortisone

 

1.6 The factors affecting diffusion current in polarography can be denoted by

(a) Nernst equation

(b) Ilkovic equation

(c) Lamberts law

(d) Mark-Houwink equation

 

1.7 Rotosort is an equipment used

(a) to separate unfilled capsules

(b) to fix the cap and body of the capsules after filling

(c) to separate the improper tablets

(d) to adjust the required compression for the tablets

1.8 As per G.M.P. permitted limit of slid contents in water for injection is:

(a) 100 ppm

(b) 1.0 ppm

(c) 0.1 ppm

(d) 10.0 ppm

 

1.9 Nujol is

(a) Hexachlorobutadiene

(b) Mineral oil

(c) Perfluorokerosene

(d) Flurolube

 

1.10 Which of the following is a microsomal enzyme inducer?

(a) Indomethacin

(b) Clofibrate

(c) Tolbutamide

(d) Glutethamide

 

1.11 Fiducial limit is a term used in

(a) microbiological assay

(b) biologically assay

(c) chemical assay

(d) instrumental methods of assay

 

1.12 Phenothiazines are metabolized

(a) in the hepatic microsomal system by hydroxylation followed by conjugation with glucuronic acid

(b) in the liver by oxidation

(c) in the hepatic microsomal system by reduction

(d) in the hepatic microsomal system by oxidation followed by conjugation withy glycine.

 

1.13 Benzodiazipines potentiate

(a) the binding of protein to nervous tissue

(b) the binding of GABA to liver

(c) the binding of GABA to receptors

(d) the binding or GABA to carbohydrates

 

1.14 Benzalkonium chloride is a germicidal surfactant which is rendered inactive in the

presence of

(a) organic acid

(b) cationic surfactants

(c) soaps

(d) inorganic salts

  

1.15 Enkephalins are

(a) exogenous compounds useful in Analgesia

(b) endogenous ligands which are pentapeptides that are localized in some nerve endings.

(c) endogenous ligands which are tripeptides that are present in nervous tissue

(d) endogenous ligands which are tetrapeptides that are present in cardiovascular tissue.

 

1.16 Benorylate is a Prodrug, chemically it is polymeric condensation product of

(a) aluminium oxide and aspirin

(b) an acetyl salicylic ester of phenol

(c) an acetyl salicylic ester of paracetamol

(d) an acetyl salicylic ester of ß -naphthol

 

1.17 Listed below are some of the common vehicles, which one is most appropriate for the

intravenous admixture of ampicillin 500 mg/50 ml?

(a) 5% Dextrose injection

(b) 5% Dextrose and 0.9% Sodium Chloride solution

(c) 2.5% Dextrose and 0.45% Sodium Chloride injection

(d) 0.9% Sodium Chloride injection

 

1.18 Acetonides are prepared to improve the bioavailability of certain drugs. Which of the

following is available as acetonide?

(a) Clonidine

(b) Prednisolone

(c) Pyrimethamine

(d) Triamicinolone

 

1.19. Which one of the following indicators is used in Complexometric Titration?

(a) Crystal Violet

(b) Murexide

(c) Eosin

(d) Methyl Orange

 

1.20. Betamethasone is:

(a) 9 α Fluro 11 ß , 17 α, 21 trihydroxy 16 ß methyl pregna-1, 4 diene 3, 20 dione

(b) 9 α Fluro 12 ß , 13 α, 21 trihydroxy 17 ß methyl pregna-1, 4 diene 3, 20 dione

(c) 9 α Fluro 11 ß , 17 α, 21 trihydroxy 16 ß methyl estra-1, 4 diene 3, 20 dione

(d) 9 α Fluro 11 ß , 17 α, dihydroxy 16 ß methyl pregna-1, 4 diene 3, 20 dione 

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